个人简介
北京理工大学教授，博士生导师。主要从事生物酶及均相催化反应机理的理论计算研究，主持国家自然科学基金4项，参加“973”计划项目课题1项。曾获得中国国家留学基金管理委员会颁发的“2008年度国家优秀自费留学生奖”，入选2015年度北京市“科技新星计划”。在催化反应机理理论和应用研究方面开展了系统的研究工作，已在J. Am. Chem. Soc.、Angew. Chem.、ACS Catalysis、J. Catalysis、Chem. -Eur. J.、J. Chem. Theory Comput.等期刊上发表SCI收录论文80余篇。
Professor and Ph.D. supervisor at Beijing Institute of Technology. Engaged in theoretical and computational research on the mechanisms of enzymatic and homogeneous catalytic reactions. Principal investigator for 4 National Natural Science Foundation projects and participated in one project under the "973" Program. Awarded the "Chinese Government Award for Outstanding Self-Financed Students Abroad" by the China Scholarship Council in 2008 and selected for the "Beijing Nova Program" in 2015. Published over 80 SCI-indexed papers in journals such as J. Am. Chem. Soc., Angew. Chem., ACS Catalysis, J. Catalysis, Chem. -Eur. J., J. Chem. Theory Comput.
研究领域和方向
生物酶与均相催化反应机理的理论研究
Theoretical research on the mechanisms of enzymatic and homogeneous catalytic reactions
教育背景
2005/11 – 2009/02，瑞典皇家工学院，生物技术学院，“生物技术”博士
2004/09 – 2008/01，北京师范大学，化学学院，“物理化学”博士
2001/09 – 2004/07，北京师范大学，化学系，“分析化学”硕士
1997/09 – 2001/07，北京师范大学，化学系，“化学教育”学士
Nov 2005 - Feb 2009: Ph.D. in Biotechnology, Royal Institute of Technology, Sweden
Sep 2004 - Jan 2008: Ph.D. in Physical Chemistry, Beijing Normal University, China
Sep 2001 - Jul 2004: M.S. in Analytical Chemistry, Beijing Normal University, China
Sep 1997 - Jul 2001: B.S. in Chemical Education, Beijing Normal University, China
工作履历
2012/07 – 至今，北京理工大学，化学与化工学院，教授
2010/10 – 2012/07，北京理工大学，化学学院，副教授
2009/04 – 2010/09，瑞典斯得哥尔摩大学，物理系，博士后
Jul 2012 – Present: Professor, School of Chemistry and Chemical Engineering, Beijing Institute of Technology
Oct 2010 - Jul 2012: Associate Professor, School of Chemistry, Beijing Institute of Technology
Apr 2009 - Sep 2010: Postdoctoral Researcher, Department of Physics, Stockholm University, Sweden
研究成果
More publications can be found in the link:
https://www.researchgate.net/scientific-contributions/Shi-Lu-Chen-39159784
[1]Ze-Han Ma, Ming-Jia Yu*, Shi-Lu Chen*, Bidirectional Electron Transfer by a [2Fe-2S]Rieske Cluster Enables HO–FeIII=O•– Chemistry for cis-Dihydroxylation, J. Phys. Chem. Letters, 2026, 17(13), 3986-3991.
[2]Jie Li, Pengpeng Shao, Peng Lei, Di Zhang, Chengpeng Liu, Shilu Chen*, Yingnan Chi*, Changwen Hu, Polyoxoniobate as a Recyclable Proton Shuttle Enabling Efficient Lignin β‑O‑4 Linkage Cleavage: Experimental and Theoretical Insights, ACS Catalysis, 2026, 16(3), 2268-2279.
[3]Zhenzhou Sun, Luomo Li, Li Yang, Shi-Lu Chen*, Xiao-Hui Yang*, Biao Wu, Xiao-Juan Yang*, Magnesium(I)-Mediated Dearomatizing Coupling of Pyridines and Subsequent Hydrogen Transfer Reactions, Chemistry – A European Journal, 2026, 32(11), e03394.
[4]Ze-Han Ma and Shi-Lu Chen*, Iron-Sulfur-Mediated C-S Bond Formation: Mechanistic Insights from the state-crossing tRNA Methylthiolation by the Radical SAM Enzyme MiaB, Chemistry – A European Journal, 2025, 31(49), e01463.
[5]Jian-Qiao Xu and Shi-Lu Chen*, Theoretical Investigation on Reaction Mechanism of Binuclear Nickel Guanidine Hydrolase, ChemCatChem, 2025, 17, e202500046.
[6]Yue Ran, Xiao-Nan Niu, Ying-Jie Wang, Wei-Hai Xu, Jian-Hua Liang*, Yan Xu*, Shi-Lu Chen*, Ming-Jia Yu*, Activation of S1PR1 by Ponesimod for Multiple Sclerosis Therapy: Uncovering MAPK and PI3K Pathway Mechanisms and Repurposing Potential, Chemistry – A European Journal, 2025, 31(48), e04742.
[7]Zicheng Liao, Zijun Li, Meiqiu Xiao, Youlin Deng, Zehan Ma, Lijuan Zhou, Gangliang Dai, Xinyu Li, Shuowen Wang, Shilu Chen*, Jinheng Li*, Shi Tang*, Asymmetric synthesis of β-amino acid derivatives by stereocontrolled C(sp3)-C(sp2) cross-electrophile coupling via radical 1,2-nitrogen migration, Nature Communications, 2025, 16, 7218.
[8]Zehan Ma and Shilu Chen*, Computational Mechanistic Insights into Non-Cubane Iron-Sulfur Cluster-Dependent Enzymes with [2Fe–2S] and [4Fe–4S] Cores: A Review, Communications in Computational Chemistry, 2025, 7(3), 249-263.
[9]Rui-Ning Li and Shi-Lu Chen*, Recent Insights into the Reaction Mechanisms of Non-Heme Diiron Enzymes Containing Oxoiron(IV) Complexes (Review), ChemBioChem, 2025, 26(3), e202400788.
[10]Ying Wang* and Shi-Lu Chen*, Reaction Mechanisms of Fe-Dependent Fatty Acid Decarboxylases (Review), ChemCatChem, 2024, 16(14),e202301501.
[11]Rui-Ning Li and Shi-Lu Chen*, Mechanistic Insights into the N-Hydroxylations Catalyzed by the Binuclear Iron Domain of SznF Enzyme: Key Piece in the Synthesis of Streptozotocin, Chemistry – A European Journal, 2024, 30(16), e202303845.
[12]Han-Xiao Wu and Shi-Lu Chen*, Enzymatic C-S bond cleavage: Mechanism for the conversion of methanesulfonate to sulfite by flavin-dependent MsuD monooxygenase, Chemical Physics, 2024, 576, 112112.
[13]Weijie Geng, Di Zhang, Ni Zhen, Jianxin Du, Jing Dong, Chengpeng Liu, Shi-Lu Chen*, Yingnan Chi*, and Changwen Hu, Electroreductive C−C Coupling of Furfural to Jet Fuel Precursors in Neutral Media via Synergistic Catalysis of the Polyoxotungstate and Cu Complex, ACS Catalysis, 2024, 14(13), 10040–10052.
[14]Yu Hong, Zi-Cheng Liao, Jia-Jie Chen, Jian Liu, Yin-Ling Liu, Jin-Heng Li*, Qing Sun*, Shi-Lu Chen*, Shuo-Wen Wang, and Shi Tang*, Radical 1,2-Nitrogen Migration Cascades of β‑Bromo α‑Amino Acid Esters to Access β‑Amino Acid Motifs Enabled by Cooperative Ni/Diboron Catalysis, ACS Catalysis, 2024, 14, 5491−5502.
[15]Ying Wang and Shi-Lu Chen*, Mechanism for the synthesis of medium-chain 1-alkenes from fatty acids catalyzed by binuclear iron UndA decarboxylase, Journal of Catalysis, 2023, 420, 123–133.
[16]Rui-Ning Li and Shi-Lu Chen*, Mechanism for the Halogenation and Azidation of Lysine Catalyzed by Non-heme Iron BesD Enzyme, Chemistry – An Asian Journal, 2022, 17, e202200438.
[17]Ying Wang and Shi-Lu Chen*, Reaction mechanism of the PuDddK dimethylsulfoniopropionate lyase and cofactor effects of various transition metal ions, Dalton Transactions, 2022, 51, 14664-14672.
[18]Jue Wu and Shi-Lu Chen*, Key Piece in the Wolfe Cycle of Methanogenesis: The S–S Bond Dissociation Conducted by Noncubane [Fe4S4] Cluster-Dependent Heterodisulfide Reductase, ACS Catalysis, 2022, 12, 2606–2622.
[19]Jian Liu, Yu Hong, Yin-Ling Liu, Jing-Ying Tan, Hao-Miao Liu, Gang-Liang Dai, Shi-Lu Chen*, Ting Liu, Jin-Heng Li*, and Shi Tang*, Nickel-Catalyzed Radical Heck-Type C(sp3)–C(sp2) Coupling Cascades Enabled by Bromoalkane-Directed 1,4-Aryl Shift: Access to Olefinated Arylalanines, Organic Letters, 2022, 24, 8192−8196.
[20]Jing-Xuan Su and Shi-Lu Chen*, A Key Piece in the Global N-cycle: The N-N Bond Formation Presented by Heme-dependent Hydrazine Synthase, ACS Catalysis, 2021, 11, 6489−6498.
[21]Hui Yang and Shi-Lu Chen*, Enzymatic N-N bond formation: Mechanism for the N-nitroso synthesis catalyzed by non-heme iron SznF Enzyme, Journal of Catalysis, 2021, 398, 44–53.