个人简介
主要从事以多肽为识别元件的靶向分子探针构建与生物医用功能材料基础与应用研究。围绕多肽动态可控自组装、功能多肽分子探针、以及神经，肿瘤精准诊疗等方面开展研究工作，为生理病理过程靶标的识别、可视化检测和靶向干预提供新工具和新策略。以通讯及第一作者在Angew. Chem. Int. Ed、 Adv. Mater、Anal. Chem、Chem. Sci、Nano. Lett 等期刊发表学术论文20余篇，其中第一及通讯作者10余篇。
研究领域和方向
1. 多肽动态可控自组装与形貌精准调控
2. 多肽基多功能分子构建
3. 面向NIR‑II区成像的多肽分子探针构建
3. 神经，肿瘤精准诊疗平台开发
教育背景
2020.09-2024.06 北京理工大学 化学 理学博士
2017.09-2020.06 中国石油大学（华东）生物化工 工学硕士
2023.09-2017.06 兰州交通大学 工学学士
工作履历
2026.09-至今 北京理工大学 预聘助理教授
2024.08-2026.08 香港大学深圳研究、香港大学 博士后（合作导师：戴宏杰院士）
研究成果
(1). Limin Zhang, Minxuan Wang, Bo Wang, Jinge Zhao, Beilei Sun, Yao Yu, Kai Han, Xin Wang, Jian Zhang, Mingshan Wei, Jingrui Deng, Jie Li, Mengzhen Li, Yubin Ke, Hanqiu Jiang, Han Yan, Xubiao Peng*, Yu Bai*, Xiaoyuan Chen*, Weizhi Wang*. Side-Chain Engineering Guides the Design of β-Sheet Inhibitor to Anchor Protein-Protein Interaction Interfaces. Angewandte Chemie International Edition. 2026,65, e21473.
(2). Limin Zhang, Mengzhen Li, Minxuan Wang, Lingyun Li, Mingmei Guo, Yubin Ke, Peng Zhou, Weizhi Wang*. Tailored cross-β assemblies establish peptide “Dominos” structures for anchoring undruggable pharmacophores. Angewandte Chemie International Edition. 2022, 61, e202212527.
(3). Limin Zhang, Zhenqi Jiang, Xi Yang, Yixia Qian, Minxuan Wang, Shang Wu, Lingyun Li, Fei Jia, Zihua Wang, Zhiyuan Hu, Minzhi Zhao, Xiaoying Tang, Gang Li, Hanbing Shang, Xiaoyuan Chen*, Weizhi Wang*. Totipotent ‘all-in-one’ peptide sequentially blocks immune checkpoint and reverses immunosuppressive tumor microenvironment. Advanced Materials. 2023, 35, e202207330.
(4). Limin Zhang, Yuwei Tian, Mengzhen, Li, Minxuan Wang, Shang Wu, Zhenqi Jiang, Qiqin Wang, Weizhi Wang*. Peptide nano ‘bead-grafting’ for SDT-facilitated immune checkpoints blocking. Chemical Science. 2022, 13, 027288035.
(5). Xin Wang, Jinge Zhao, Jian Zhang, Jingtian Cao, Yao Yu, Bokai Ma, Guangle Niu, Shixiang Lu, Limin Zhang*, and Weizhi Wang*. π–π Stacking Network-Based Supramolecular Peptide Nanoprobe for Visualization of the ICB-Enhanced Ferroptosis Process. Analytical Chemistry. 2024, 96, 13317.
(6). Limin Zhang, Xin Wang, Jinge Zhao, Ying Qi, Kai Han, Yao Yu, Bokai Ma, Yubin Ke, Guangle Niu*, Weizhi Wang*. Harnessing Cross-strand π–π Interlocking for Synergistic Enhancement of Immune Checkpoint Blocking and Ferroptosis. Nano Letters. 2024, 24, 15396.
(7) Limin Zhang, Zhiwei Yin, Minxuan Wang, Beilei Sun, Bo Wang, Kai Han, Jinge Zhao, Mingshan Wei, Jingrui Deng and Weizhi Wang*. Targeting peptide-mediated nanoparticle transport and antitumor efficacy research based on spatial proteomics. Chemical. Communications. 2026, 62, 15335-15338.
(8). Limin Zhang, Xin Wang, Jinge Zhao, Beilei Sun, Weizhi Wang*. Construction of Targeting-peptide-based Imaging Reagents and their Application in Bioimaging. Chemical & Biomedical Imaging. 2024, 2, 233.
(9). Yuwei Tian#, Limin Zhang#, Fangjie Liu, Minxuan Wang, Lingyun Li, Mingmei Guo, Hangyu Xu, Zhiying Yu, Weizhi Wang*. Multi-stage responsive peptide nanosensor: Anchoring EMT and mitochondria with enhanced fluorescence and boosting tumor apoptosis. Biosensors and Bioelectronics. 2021, 184, 113235.
(10). Limin Zhang, Jinge Zhao, Bokai Ma, Xin Wang, Jian Zhang, Weizhi Wang*. Enhanced Molecular Imaging through a Versatile Peptide Nanofiber for Self‐assembly and Precise Recognition. ChemBioChem. 2025, 26, e202400753
(11). Zhiwei Yin#, Limin Zhang#, Rui Shi, Xin Xia, Zhaoxin Wang, Ling Li* and Zhuo Chen. Mechanical-Enhanced Porous Silk-Based Cryogenic Microneedles for Cell Thawing/Revival in the Gastric Wall. Polymers, 2026, 18, 1654