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张小玲

作者:化学学院 | 发布日期:2013-11-19  |  浏览量:  

姓名:张小玲
性别:
出生年月:1963.3
职务职称:教授,博士生导师
联系电话:68913154
传真:010-88875298
电子邮件:
zhangxl000@126.comzhangxl@bit.edu.cn

主要经历:
  
分别于1984年、1987年陕西师范大学化学系获理学学士、硕士学位,随后留校任教。2003年获西北大学分析化学专业博士学位,2005年调入北京理工大学理学院化学系任教授、博士生导师。期间2005年12月应日本筑波产业技术综合研究所(NationalInstitute of Advanced Industrial Science and Technology,AIST)邀请作为特聘研究员从事研究工作,2008-2009年美国佛罗里达大学(University of  Florida)访问教授。主要从事新型光学探针试剂及功能化纳米晶的设计合成及其在分子识别与化学生物传感中的应用研究。

研究方向:
1.        新型光学探针分子的设计、合成
2.        功能化纳米晶及纳米结构的设计、合成、组装
3.        分子识别与化学生物传感

研究内容:
  
针对目前环境污染、食品安全、疾病的早期诊断及药物靶向治疗等人类所面对的问题中所必需的高灵敏度、高特异性化学生物识别传感学方法和器件研究,利用光诱导电子转移、电荷转移、能量转移等各种光物理过程,和酶、抗体、单链DNA和核酸识体、信号肽等生物分子识别物质,设计合成性能优异的光学(包括吸光、荧光、发光)探针分子或功能化纳米晶,构建组装针对不同目标物的分子和生物纳米识别体系,实现对生命体系或环境体系中重要目标物(包括阴阳离子,中性小分子,生物大分子,病毒,细菌,肿瘤细胞,病变组织等)的光电化学识别传感,探索识别机制及其化学本质,应用于对生命、环境、食品等复杂体系中具有重要影响力目标物的特异性标记和远程、活体、原位、实时检测或显微成像分析等。

承担课题:主持或参加国家自然科学基金及其他军工项目多项:
1.        国家自然科学基金资助项目“近红外分子/纳米荧光探针制备及其在肿瘤分子成像分析中的应用研究”,主持人
2.        信号肽介导亚细胞区域靶位近红外Ca2+荧光纳米传感器的研究,国家自然科学基金项目
3.        高选择性硫醇探针的设计合成及分析应用,北京分子科学国家实验室开放课题基金
4.        推进剂装药老化性能表征方法研究,横向
5.        火炸药原材料数据库,横向

主要成果:已发表学术论文百余篇,申请国家发明专利6项,参编或主编出版教材4部,获省科技进步二等奖两项。
Selected Publications:

1.        Xiaoman Zhai,  Wen Yang*,Mengyao Li,Guiqin Lv, Jinping Liu and Xiaoling Zhang*,Noncovalent hybrid of CoMn2O4 spinel nanocrystals and poly (diallyldimethylammonium chloride) functionalized carbon nanotubes as efficient electrocatalysts for oxygen reduction reaction, Carbon, 2013, 65:277-286
2.        Fang Zhang, Simiao Niu, Wenxi Guo, Guang Zhu, Ying Liu, Xiaoling Zhang, and Zhong Lin Wang, Piezo-phototronic Effect Enhanced Visible/UV Photodetector of a Carbon-Fiber/ZnO-CdS Double-Shell Microwire, ACS NANO, 2013, 7(5): 4537-4544.
3.        Fang Zhang, Yan Fang, Xiaoling Zhang*, Fluorescence Emission Properties of C60 Nanoparticles. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2013, 106:242-6.
4.        Xiaodan Zeng, Xiaoling Zhang *, Baocun Zhu, Hongying Jia and Yamin Li, A Highly Selective Wavelength-Ratiometric And Colorimetric Probe For Cysteine, Dyes and Pigments., 2012, 94(1):10-15. 
5.        Xiaodan Zeng, Xiaoling Zhang *, WenYang *,Hongying Jia and Yamin Li, Fluorescence detection of adenosine triphosphate through an aptamer–molecular beacon multiple probe, Analytical Biochemistry, 2012, 424(1): 8–11.
6.        Xiaomiao Hou, Xiaoling Zhang *, Shutang Chen, Huaizhi Kang, Weihong Tan *,Facile synthesis of Ni/Au‚ Ni/Ag hybrid magnetic nanoparticles New active substrates for surface enhanced Raman scattering, Colloids and Surfaces A: Physicochemical and Engineering Aspects , 2012, 403: 148-154
7.        Liguo Wang, Qi Zhou, Baocun Zhu*, Liangguo Yan, Zhenmin Maa, Bin Du, Xiaoling Zhang*,A colorimetric and fluorescent chemodosimeter for discriminative and simultaneous quantification of cysteine and homocysteine, Dyes and Pigments, 2012,95275-279.
8.        Xiaomiao Hou, Xiaoling Zhang *, Wen Yang*, Yu Liu, Xiaoman Zhai , Synthesis of SERS active Ag2S nanocrystals using oleylamine as solvent‚ reducing agent and stabilizer, Materials Research Bulletin, 2012,47: 2579–2583.
9.        Xiaoman Zhai , Xiaoling Zhang *, Shutang Chen,Wen Yang*,Zheng Gong,Oleylamine as solvent and stabilizer to synthesize shape-controlled ZnS nanocrystals with good optical properties,  Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2012,409:126-129
10.     Fang Zhang, Yong Ding, Yan Zhang, Xiaoling Zhang, and Zhong Lin Wang, Piezo-phototronic Effect Enhanced Visible and Ultraviolet Photodetection Using a ZnO-CdS Core-Shell Micro/nanowire, ACS NANO, 2012, 6(10): 9229-9236.
11.     Huaizhi Kang, Haipeng Liu, Xiaoling Zhang*, Jilin Yan, Zhi Zhu, Lu Peng, Huanghao Yang, Youngmi Kim and Weihong Tan*, Photoresponsive DNA-Crosslinked Hydrogels for Controllable Release and Cancer Therapy, Langmuir, 2011, 27(1), 399-408. (This work has been highlighted by NATURE, 2011, 470: 9, 3 FEBRUARY, 2011)
12.     Yamin Li , Xiaoling Zhang*, Baocun Zhu, Juan Xue, Zhi Zhu and Weihong Tan*,A simple but highly sensitive and selective colorimetric and fluorescent probe for Cu2+ ion aqueous media, Analyst, 2011, 136, 1124-1128. (Was one of the top five most-read articles from the online version of Analyst for January 2011.)
13.     Yamin Li , Xiaoling Zhang*, Baocun Zhu, Juan Xue, Jilin YAN, A Disulfide-linked Naphthalimide Dimer for Hg(II) Detection in Aqueous Solution, JOURNAL OF FLUORESCENCE,2011,21(4)1343-1348
14.     Shutang Chen, Xiaoling Zhang*, Qiuhua Zhang, Xiaomiao Hou, Qi Zhou , Jilin Yan ,Weihong Tan* . CdSe quantum dots decorated by mercaptosuccinic acid as fluorescence probe for Cu2+, Journal of Luminescence, 2011, 131 , 947–951.
15.     Xiaomiao Hou, Xiaoling Zhang*, Shutang Chen,Yan Fang, Jilin Yan, NaLi, Pengxu Qi. Facile synthesis of SERS active Ag nanoparticles in the presence of tri-n-octylphosphine sulfide, Applied Surface Science, 2011, 257,  4935-4940
16.     Na Li, Xiaoling Zhang*, Shutang Chen, Xiaomiao Hou, Yu Liu, Xiaoman Zhai.  Synthesis and Optical Properties of CdS nanorods and CdSe nanocrystals Using Oleylamine as both Solvent and Stabilizer, Materials Science and Engineering B, 2011,176 (8): 688-691.
17.     Xiaomiao Hou, Xiaoling Zhang*, Shutang Chen, Yan Fang, Na Li, Xiaoman Zhai, Yu Liu. Size-controlled synthesis of Au nanoparticles and nanowires and their application as SERS substrates. Colloids and Surfaces A: Physicochem. Eng. Aspects, 2011, 384(1-3): 345-351.
18.     Kang, Huaizhi; Trondoli, Anna; Zhu, Guizhi; Chen, Yan; Chang, Ya-Jen; Liu, Haipeng; Huang, Yu-Fen; Zhang, Xiaoling*; Tan, Weihong* . Near-Infrared Light-Responsive Core-Shell Nanogels for Targeted Drug Delivery, ACS Nano, 2011, 5 (6): 5094–5099.
19.     Na Li, Xiaoling Zhang*, Shutang Chen, Xiaomiao Hou. Synthesis and Characterization of CdS Nanoparticles in the Presence of Oleic Acid as Solvent and Stabilizer. Journal of Physics and Chemistry of Solids,2011,721195-1198.
20.     Baocun Zhu, Fang Yuan, Rongxia Li, Yamin Li, Qin Wei, Zhenmin Ma*, Bin Du,* and Xiaoling Zhang*,A highly selective colorimetric and ratiometric fluorescent chemodosimeter for imaging fluoride ion in living cells,Chem. Commun., 2011, 47: 7098-7100.
21.     Baocun Zhu, Chenchen Gao, Yunzhou Zhao, Caiyun Liu, Yamin Li, Qin Wei, Zhenmin Ma, Bin Du* and Xiaoling Zhang*,A 4-hydroxynaphthalimide-derived ratiometric fluorescent chemodosimeter for imaging palladium in living cells,Chem. Commun., 2011,47, 8656–8658.
22.     Na Li, Xiao Ling Zhang*, Shu Tang Chen, Wen Yang, Zhi Hui Kang, Wei Hong Tan. One-pot Self-Assembly of Flower-like Cu2S Structures with Near-Infrared Photoluminescent Properties. CrystEngComm. 2011, 13 (21), 6549 - 6554
23.     Xiaodan Zeng, Xiaoling Zhang *, Baocun Zhu, Hongying Jia, Wen Yang*, Yamin Li and Juan Xue, A colorimetric and ratiometric fluorescent probe for quantitative detection of GSH at physiologically relevant levels,Sensors & Actuators: B. Chemical,2011,159(1): 142-147
24.     Xiaodan Zeng, Xiaoling Zhang *, Baocun Zhu, Hongying Jia and Yamin Li, A colorimetric and ratiometric fluorescent probe for quantification of bovine serum albumin,Analyst , 2011, 136 (19), 4008 - 4012
25.     Shutang Chen,Xiaoling Zhang* ,Xiaomiao Hou,Qi Zhou, Weihong Tan, Synthesis of CdS–Au2S–Au hybrid dendritic nanostructures,Materials Letters,2010, 64(1): 489-492
26.     Zhang Fang, Zhang Xiaoling*, On the fluorescence of C60 at room temperature, SCIENCE CHINA(Physics, Mechanics & Astronomy), 2010,53(1): 95-99
27.     Baocun Zhu, Xiaoling Zhang, Hongyin Jia, Yamin Li, Shutang Chen and Sichun Zhang ,The Determination Of Thiols Based Using A Probe That Utilizes Both An Absorption Red-Shift And Fluorescence Enhancement, Dyes and Pigments, 2010,8687-92.
28.     Baocun Zhu, Xiaoling Zhang*, Hongyin Jia, Yamin Li, Haipeng Liu,Weihong Tan.   Title : A highly selective ratiometric fluorescent probe for 1,4-dithiothreitol (DTT) detection , Organic & Biomolecular Chemistry, 2010, 87,1650 - 1654.
29.     Baocun Zhu, Hongyin Jia, Xiaoling Zhang*, Yan Chen, Haipeng Liu,Weihong Tan. Engineering a Subcellular Targetable, Red-Emitting and Ratiometric Fluorescent Probe for Ca2+ and Its Bioimaging Applications, Anal Bioanal Chem, 2010, 397:1245–1250
30.     Shutang Chen,Xiaoling Zhang* ,Xiaomiao Hou,Qi Zhou, Weihong Tan, One-pot synthesis of PbSe hollow single-crystalline nanoboxes based on gas bubble assisted Ostwald ripening ,Crystal Growth & Design, 2010,103, 1257–1262
31.     Zhi Zhu, Cuichen Wu, Haipeng Liu, Yuan Zou, Xiaoling Zhang, Huaizhi Kang, Chaoyong James Yang,* and Weihong Tan*, An Aptamer Cross-Linked Hydrogel as a Colorimetric Platform for Visual Detection, Angew. Chem. Int. Ed. 2010, 49, 1052 –1056
32.     Shutang Chen,Xiaoling Zhang* ,Yanbing Zhao, Qiuhua Zhang, Effects of Reaction Temperature on the Size and Optical Properties of CdSe Nanocrystals, Bulletin of Materials Science,2010, 335):1–6.
33.     Shutang Chen,Xiaoling Zhang* ,Binkun Chen, Qiuhua Zhang, Weihong Tan*,  ,Synthesis, characterization and photoluminescence of CdS hyperbranched nanocrystals by a simple solution chemistry methods,  Journal of Nanoscience and Nanotechnology,2010,109):5857-5863.
34.     Shutang Chen,Xiaoling Zhang* ,Qiuhua Zhang, Jilin Yan, Weihong Tan, Synthesis, Characterization and Optical Properties of CdS nanorods by a Simple Solution Chemistry Method , Materials Science and Engineering B, 2010, 166, 158-162
35.     陈书堂,张小玲*,侯晓淼,周琦,CdS纳米棒的制备、表征及其形成机理,物理化学学报,201026 (02): 511-514
36.     Zhi Zhu, Ronghua Yang, Mingxu You, Xiaoling Zhang, Yanrong Wu and Weihong Tan*,Single-Walled Carbon Nanotube as an Effective  Quencher, Analytical and Bioanalytical Chemistry,2010,396:73–83
37.     Lili Chen, Weiwei Tan, Jingbo Zhang, Xiaowen Zhou, Xiaoling Zhang, Yuan Linb,Fabrication of high performance Pt counter electrodes on conductive plastic substrate for flexible dye-sensitized solar cells, Electrochimica Acta, 2010, 55(11) : 3721–3726
38.     Li Li Chen, Jia Liu, Jing Bo Zhang, Xiao Wen Zhou, Xiao Ling Zhang*,Yuan Lin*, Low temperature fabrication of flexible carbon counter electrode on ITO-PEN for dye-sensitized solar cells, Chinese Chemical Letters, 2010, 21(9): 1137-1140.
39.     Xiaomiao Hou, Xiaoling Zhang*, Yan Fang, Shutang Chen, Qi Zhou, Surface-enhanced Raman scattering of C60 on co-modified substrate of Fe3O4 and Au nanoparticles, Chemical Physics, 2010, 372: 1-5.封面文章
40.     Xiaomiao Hou, Xiaoling Zhang*, Yan Fang, Shutang Chen, NaLi, Qi Zhou, 1-Hexadecylamine as both Reducing Agent and Stabilizer to Synthesize Au, Ag Nanoparticles and Their SERS Application, Journal of Nanoparticle Research,2010, 13(5): 1929-1936
41.     Xiaomiao Hou, Xiaoling Zhang*, Yan Fang, Shutang Chen, NaLi, Qi Zhou, Synthesis of SERS Active Au Nanowires in Different Noncoordinating Solvents,  Journal of Nanoparticle Research. 2010,13(6): 2625-2632
42.     Baocun Zhu, Xiaoling Zhang*, Yamin Li, Pengfei Wang,* Hongyan Zhang, and Xiaoqing Zhuang, A colorimetric and ratiometric fluorescent probe for thiols and its bioimaging applications, Chem. Commun., 2010, 46, 5710 - 5712.
43.     ZHENG HaiRong*, XU LiangMin1, ZHANG ZhengLong, DONG Jun, CHEN ShuTang & ZHANG XiaoLing*, Fluorescence enhancement of acridine orange in a water solution by Au nanoparticles. SCIENCE CHINA Physics, Mechanics & Astronomy, 2010, 53(10): 1799–1804,
44.     Yamin Li , Xiaoling Zhang*, Baocun Zhu, Jilin YAN, and Weiping XU, A Highly Selective Colorimetric and “off-on-off” Fluorescent Probe for Fluoride Ion, Analytical Sciences, 2010, 26, 1077-1080.
45.     Fang Zhang and Xiaoling Zhang*, Solvent-induced Optical Properties of C60, Journal of Luminescence, 2010, 130, 787-791.
46.     Huaizhi Kang, Haipeng Liu, Xiaoling Zhang*, Jilin Yan, Zhi Zhu, Lu Peng, Huanghao Yang, Youngmi Kim and Weihong Tan*, Photoresponsive DNA-Crosslinked Hydrogels for Controllable Release and Cancer Therapy, Langmuir, 2010, 27, 399-408. (This work has been highlighted by NATURE, 2011, 470: 9, 3 FEBRUARY, 2011)
47.     Shutang Chen, Xiaoling Zhang*, Yanbing Zhao, Jilin Yan and Weihong Tan. Preparation and Characterization of CdSe Nanoparticles in the Presence of Triocytlphosphine as Solvent and Capping Agent.  Materials Letters,2009, 63(8): 712-714
48.     Liu, Weimin; Xu, Liwei; Zhang, Hongyan; You, Juanjuan; Zhang, Xiaoling*; Sheng, Ruilong; Li, Huaping; Wu, Shikang; Wang, Pengfei.   Dithiolane linked thiorhodamine dimer for Hg2+ recognition in living cells. Organic & Biomolecular Chemistry, 2009, 7(4), 660-664.
49.     Yu-Fen Huang, Dihua Shangguan, Haipeng Liu, Joseph A. Phillips, Xiaoling Zhang,Yan Chen, and Weihong Tan. Molecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor cells. ChemBioChem, 2009, 105, 862-868.
50.     Shutang Chen, Xiaoling Zhang*, Qiuhua Zhang, Weihong Tan*,Trioctylphosphine as both solvent and stabilizer to synthesize CdS nanorods,Nanoscale Research Letters, 2009, 4:1159–1165
51.     张芳,张小玲*C60室温荧光发射现象研究,中国科学(G辑),20093912):1710-1715
52.     Xianwu Zou, Tefu Qin, Luohua Huang, Xiaoling Zhang, Zhi Yang, and Yong Wang,Mechanisms and Main Regularities of Biomass Liquefaction with Alcoholic Solvents, Energy Fuels, 2009, 23, 5213–5218